Porphyromonas gingivalis

Data on Porphyromonas gingivalis Described by Researchers at University of Alabama

Published in Vaccine Weekly, June 29th, 2011

2011 JUN 29 -- According to a study from Birmingham, United States, "Recombinant hemagglutinin B (rHagB), a virulence factor of the periodontal pathogen Porphyromonas gingivalis, has been shown to induce protective immunity against bacterial infection. Furthermore, we have demonstrated that rHagB is a TLR4 agonist for dendritic cells."

"However, it is not known how rHagB dendritic cell stimulation affects the activation and differentiation of T cells. Therefore, we undertook the present study to examine the role of TLR4 signaling in shaping the CD4(+) T cell response following immunization of mice with rHagB. Immunization with this Ag resulted in the...

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Source: Vaccine Weekly (2011-06-29)

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