Vaccines

Research from T.V. Axelsen and Co-Authors Yields New Data on Vaccines

Published in Vaccine Weekly, July 13th, 2011

2011 JUL 13 -- According to the authors of a study from Risskov, Denmark, "Alzheimer's disease (AD) is characterized by neurofibrillary tangles, consisting of hyperphosphorylated tau protein and senile plaques, which are consisting mainly of amyloid-beta (A beta). Attempts to generate a safe vaccine against A beta rely on both B- and T-cell epitopes within the neurotoxic peptide A beta 1-42."

"This, however, poses a risk for an inflammatory and/or autoimmune response against A beta-peptides in the brain. To overcome such risks we wanted to identify the shortest C-terminal A beta-peptide that would induce antibodies selectively recognizing the C-terminal end...

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Source: Vaccine Weekly (2011-07-13)

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