Vaccines

Data on Vaccines Reported by Researchers at Beth Israel Deaconess Medical Center

Published in Vaccine Weekly, July 13th, 2011

2011 JUL 13 -- According to the authors of recent research from Boston, United States, "We have developed a cancer vaccine in which autologous tumor is fused with dendritic cells (DCs) resulting in the presentation of tumor antigens in the context of DC-mediated costimulation. In clinical trials, immunologic responses have been observed, however responses may be muted by inhibitory pathways."

"The PD1/PDL1 pathway is an important element contributing to tumor-mediated immune suppression. In this study, we demonstrate that myeloma cells and DC/tumor fusions strongly express PD-L1. Compared with a control population of normal volunteers, increased PD-1...

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Source: Vaccine Weekly (2011-07-13)

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