Cancer Vaccines

Study Findings from Shanghai Jiao Tong University Broaden Understanding of Cancer Vaccines

Published in Vaccine Weekly, July 20th, 2011

2011 JUL 20 -- According to the authors of recent research from Shanghai, People's Republic of China, "The gene MTDH/AEG-1 is overexpressed in more than 40% of breast cancer patients, and it is associated with poor clinical outcomes. Previous studies have indicated that MTDH/AEG-1 could promote metastatic lung-seeding and enhance chemoresistance."

"Therefore, MTDH/AEG-1 could be a candidate target against breast cancer lung metastasis. We demonstrated that MTDH/AEG-1-based DNA vaccine, delivered by attenuated Salmonella typhimurium, could evoke strong CD8(+) cytotoxic-T-cell mediated immune responses against breast cancer. This vaccine showed anti-tumor...

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Source: Vaccine Weekly (2011-07-20)

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