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Data on Vaccines Detailed by Researchers at University of Leiden

Published in Vaccine Weekly, July 20th, 2011

2011 JUL 20 -- Investigators publish new data in the report "Small is beautiful: N-trimethyl chitosan-ovalbumin conjugates for microneedle-based transcutaneous immunisation." According to the authors of a study from Leiden, Netherlands, "To provoke an immune response, a transcutaneously administered vaccine has to diffuse into the skin, reach the lymph nodes and be taken up by dendritic cells (DCs). To study these three steps we immunised mice transcutaneously (with microneedles), intradermally and intranodally."

"The effect of the formulation was investigated by formulating ovalbumin (OVA) in three ways with N-trimethyl chitosan (TMC): TMC+OVA mixtures,...

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