Salmonella

Studies from Yale University School of Medicine Provide New Data on Salmonella

Published in Vaccine Weekly, August 31st, 2011

2011 AUG 31 -- Data detailed in "A mouse model for the human pathogen Salmonella typhi" have been presented. "Salmonella enterica serovar Typhi (S. typhi) causes typhoid fever, a life-threatening human disease. The lack of animal models due to S. typhi's strict human host specificity has hindered its study and vaccine development," scientists in New Haven, Connecticut report.

"We find that immunodeficient Rag2(-/-) 'c(-/-) mice engrafted with human fetal liver hematopoietic stem and progenitor cells are able to support S. typhi replication and persistent infection. A S. typhi mutant in a gene required for virulence in humans was...

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Source: Vaccine Weekly (2011-08-31)

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