HIV/AIDS

New HIV/AIDS Data Have Been Reported by Researchers at Duke University

Published in Vaccine Weekly, September 7th, 2011

2011 SEP 7 -- "We have developed a high-throughput platform to detect the presence of HIV-1 and SIV-specific ADCC-mediating antibody responses. The assay is based on the hydrolysis of a cell-permeable fluorogenic peptide substrate containing a sequence recognized by the serine protease, Granzyme B (GzB)," researchers in Durham, North Carolina report.

"GzB is delivered into target cells by cytotoxic effector cells as a result of antigen (Ag)-specific Ab-Fc gamma receptor interactions. Within the target cells, effector cell-derived GzB hydrolyzes the substrate, generating a fluorescent signal that allows individual target cells that have received a lethal hit...

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Source: Vaccine Weekly (2011-09-07)

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