Research from Center for Cancer Research in the Area of Vaccines Described

2011 OCT 5 -- A report, "Maturation of human dendritic cells with Saccharomyces cerevisiae (yeast) reduces the number and function of regulatory T cells and enhances the ratio of antigen-specific effectors to regulatory T cells," is newly published data in Vaccine. "We compared the effects of yeast-treated human dendritic cells (DCs) with CD40L-matured human DCs for the induction of effector cells and the number and functionality of CD4(+)CD25(+)CD127(-)FoxP3(+) regulatory T cells (Tregs). DCs were treated with yeast or CD40L and cocultured with isolated autologous CD4(+) T cells," researchers in Bethesda, Maryland report.

"CD4(+)CD25(+)CD127(-) T...

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