2011 OCT 5 -- "The development of effective immunoprophylaxis against tuberculosis (TB) remains a global priority, but is hampered by a partially protective Bacillus Calmette-Guerin (BCG) vaccine and an incomplete understanding of the mechanisms of immunity to Mycobacterium tuberculosis. Although host genetic factors may be a primary reason for BCG's variable and inadequate efficacy, this possibility has not been intensively examined," scientists in Newark, New Jersey report.
"We hypothesized that Toll-like receptor (TLR) variation is associated with altered in vivoimmune responses to BCG. We examined whether functionally defined TLR pathway polymorphisms...
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