Vaccines
Data from Duke University Provide New Insights into Vaccines
Published in Vaccine Weekly, October 12th, 2011
2011 OCT 12 -- According to the authors of a study from Durham, North Carolina, "Lymphodepletion augments adoptive cell transfer during antitumor immunotherapy, producing dramatic clinical responses in patients with malignant melanoma. We report that the lymphopenia induced by the chemotherapeutic agent temozolomide (TMZ) enhances vaccine-driven immune responses and significantly reduces malignant growth in an established model of murine tumorigenesis."
"Unexpectedly, despite the improved antitumor efficacy engendered by TMZ-induced lymphopenia, there was a treatment related increase in the frequency of immunosuppressive regulatory T cells (T-Regs; P =...
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Source: Vaccine Weekly (2011-10-12)
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