2011 OCT 12 -- According to the authors of recent research published in the journal Infection and Immunity, "Escherichia coli causes about 90% of urinary tract infections (UTI), and more than 95% of all UTI-causing E. coli express type 1 fimbriae. The fimbrial tip-positioned adhesive protein FimH utilizes a shear force-enhanced, so-called catch-bond mechanism of interaction with its receptor, mannose, where the lectin domain of FimH shifts from a low-to a high-affinity conformation upon separation from the anchoring pilin domain."
"Here, we show that immunization with the lectin domain induces antibodies that exclusively or predominantly recognize...
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