Vaccines

Studies from University of Tel Aviv Yield New Information about Vaccines

Published in Vaccine Weekly, November 2nd, 2011

2011 NOV 2 -- "We identified a 4 year-old boy born to a consanguineous marriage with C3 deficiency after three episodes of invasive pneumococcal disease. The efficacy of anti-pneumococcal vaccination in C3 deficient patients is not clear," scientists in Tel Aviv, Israel report.

"Our objective was to identify the genetic defect resulting in his C3 deficiency and measure his ability to mount an adaptive immune response. Fibroblast cell lines were generated from the patient and parents. DNA was isolated and the C3 gene sequenced. Quantitation of C3 expression was performed by immunoprecipitation of 355-methionine labeled protein. Isotype specific...

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Source: Vaccine Weekly (2011-11-02)

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