Vaccines

Study Results from University of Tehran Broaden Understanding of Vaccines

Published in Vaccine Weekly, November 2nd, 2011

2011 NOV 2 -- According to the authors of a study from Tehran, Iran, "Genetic adjuvants have potential role in improvement of immune responses against DNA vaccines. GMCSF as a genetic adjuvant can recruit and augment dendritic cell numbers in the site of immune responses and thereby induce cellular and humorat immune responses."

"Here we show that co-immunization of a DNA vaccine from HIV-1P24-Nef with GM-CSF in DNA priming and peptide boost strategy increases the immunogenicity of our candidate vaccine. Analysis of immune response shows that co-immunization with GM-CSF boosts cellular immune responses through increasing proliferation activity and CTL...

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Source: Vaccine Weekly (2011-11-02)

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