Vaccines

Recent Findings from T.J. Moraes and Co-Authors Highlight Research in Vaccines

Published in Vaccine Weekly, November 2nd, 2011

2011 NOV 2 -- "T cell based influenza vaccines offer the potential for cross protective immunity to multiple clades of influenza virus. Here we explored the effect of increasing CD8 T cell responses during intranasal vaccination by incorporating a T cell costimulator, 4-1BBL," investigators in Toronto, Canada report.

"Inclusion of 4-1BBL in an influenza nucleoprotein (NP)-containing adenoviral vector increased the number of NP-specific CD8 T cells and lowered the vaccine dose required for short-term protection from influenza-induced disease in mice. At higher vaccine doses, the inclusion of 4-1 BBL increased the duration of protection of mice from...

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Source: Vaccine Weekly (2011-11-02)

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