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Study Findings from University of Freiburg Broaden Understanding of Vaccines

Published in Vaccine Weekly, November 9th, 2011

2011 NOV 9 -- According to the authors of recent research published in the journal Vaccine, "Influenza B virus infections are mainly restricted to humans, which is partially caused by the inability of influenza B virus NS1 protein to counteract the innate immune response of other species. However, for cell culture-based influenza vaccine production non-human cells, such as Madin-Darby canine kidney (MDCK) cells, are commonly used."

"Therefore, the impact of cellular pathogen defence mechanisms on influenza B virus propagation in MDCK cells was analysed in this study. Activation of the cellular antiviral defence by interferon stimulation slowed down...

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