Simian Immunodeficiency Virus

Research from National Cancer Institute Provides New Data about Simian Immunodeficiency Virus

Published in Vaccine Weekly, December 14th, 2011

2011 DEC 14 -- "TRIM5 alpha is a natural resistance factor that binds retroviral capsid proteins and restricts virus replication. The B30.2/SPRY domain of TRIM5 alpha is polymorphic in rhesus macaques, and some alleles are associated with reduced simian immunodeficiency virus (SIV) SIVmac251 and SIVsmE543 replication in vivo," scientists in Bethesda, Maryland report.

"We determined the distribution of TRIM5 alpha alleles by PCR and sequence analysis of the B30.2/SPRY domain in a cohort of 82 macaques. Thirty-nine of these macaques were mock vaccinated, 43 were vaccinated with either DNA-SIV/ALVAC-SIV/gp120, ALVAC-SIV/gp120, or gp120 alone, and all were...

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Source: Vaccine Weekly (2011-12-14)

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