Vaccines
New Vaccines Data Have Been Reported by Researchers at University of Pretoria
Published in Vaccine Weekly, December 21st, 2011
2011 DEC 21 -- Investigators discuss in "Characterization of the interactions of the pneumolysoid, '6 PLY, with human neutrophils in vitro" new findings in Vaccines. According to the authors of recent research from Pretoria, South Africa, "The pneumolysin toxoid, '6 PLY, is a prototype pneumococcal protein vaccine candidate. However, its potentially detrimental residual pro-inflammatory interactions with human neutrophils are unknown."
"In the current study the effects of the toxoid (8-1000 ng/ml) have been compared with those of wild-type pneumolysin (WT/PLY, 8 ng/ml) on neutrophil cytosolic Ca(2+) fluxes, generation of leukotriene B(4) (LTB(4)), and...
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Source: Vaccine Weekly (2011-12-21)
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