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Plague Vaccines

Research Conducted at University of Gdansk Has Provided New Information about Plague Vaccines

Published in Vaccine Weekly, January 18th, 2012

2012 JAN 18 -- A new study, "Structural insights into Ail-mediated adhesion in Yersinia pestis," is now available. According to the authors of a study from Bethesda, Maryland, "Ail is an outer membrane protein from Yersinia pestis that is highly expressed in a rodent model of bubonic plague, making it a good candidate for vaccine development. Ail is important for attaching to host cells and evading host immune responses, facilitating rapid progression of a plague infection."

"Binding to host cells is important for injection of cytotoxic Yersinia outer proteins. To learn more about how Ail mediates adhesion, we solved two high-resolution crystal structures...

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