Diabetes

Seasonal changes may influence the efficacy of vaccination against diabetes

Published in Vaccine Weekly, February 15th, 2012

2012 FEB 15 -- The development of a medicine for patients with type 1 diabetes mellitus, based on autoantigen GAD65, received a setback following crucial clinical phase 3 trials that failed to show significant effects. One possible explanation may be seasonal variations in the immune system, claim those responsible for the study that was published in the New England Journal of Medicine (NEJM).

At the onset of type 1 diabetes mellitus, the immune system attacks the insulin-producing pancreatic beta-cells. In conjunction with this development antibodies are often directed against different proteins/antigens in the beta-cells. The GAD65 is such an antigen, an...

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Source: Vaccine Weekly (2012-02-15)

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