Cancer Vaccines

Reports from Hokkaido University Advance Knowledge in Cancer Vaccines

Published in Vaccine Weekly, February 22nd, 2012

2012 FEB 22 -- "A patient with pulmonary metastasis of colon cancer was treated with artificially synthesized helper/killer-hybrid epitope long peptide (H/K-HELP) of MAGE-A4 cancer antigen. The patient was vaccinated with MAGE-A4-H/K-HELP combined with OK432 and Montanide ISA-51," scientists writing in the journal Cancer Science report.

"There were no severe side-effects except for a skin reaction at the injection site. MAGE-A4-H/K-HELP induced MAGE-A4-specific Th1 and Tc1 immune responses and the production of MAGE-A4-specific complement-fixing IgG antibodies. Tumor growth and carcinoembryonic antigen tumor marker were significantly decreased in the...

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Source: Vaccine Weekly (2012-02-22)

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