Cancer Vaccines
Research from University of California in the Area of Cancer Vaccines Described
Published in Vaccine Weekly, February 29th, 2012
2012 FEB 29 -- Data detailed in "Targeted therapeutic remodeling of the tumor microenvironment improves an HER-2 DNA vaccine and prevents recurrence in a murine breast cancer model" have been presented. "The tumor microenvironment (TME) mediates immunosuppression resulting in tumor cell escape from immune surveillance and cancer vaccine failure. Immunosuppression is mediated by the STAT-3 transcription factor, which potentiates signaling in tumor and immune cells," scientists in La Jolla, California report.
"Because immunosuppression continues to be a major inhibitor of cancer vaccine efficacy, we examined in this study whether therapeutically targeted...
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Source: Vaccine Weekly (2012-02-29)
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