Viral Vaccines
New Viral Vaccines Findings from University of Munich Published
Published in Vaccine Weekly, February 29th, 2012
2012 FEB 29 -- According to the authors of a study from Munich, Germany, "Transcriptional induction of beta interferon (IFN-beta) through pattern recognition receptors is a key event in the host defense against invading viruses. Infection of cells by paramyxoviruses, like measles virus (MV) (genus Morbillivirus), is sensed predominantly by the ubiquitous cytoplasmic helicase RIG-I, recognizing viral 5'-triphosphate RNAs, and to some degree by MDA5."
"While MDA5 activation is effectively prevented by the MV V protein, the viral mechanisms for inhibition of MDA5-independent induction of IFN-beta remained obscure. Here, we identify the 186-amino-acid MV C...
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Source: Vaccine Weekly (2012-02-29)
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