2012 MAR 7 -- Research findings, "NKT Cell Stimulation with a-Galactosylceramide Results in a Block of Th17 Differentiation after Intranasal Immunization in Mice," are discussed in a new report. According to the authors of a study from Braunschweig, Germany, "In a previous study we demonstrated that intranasal (i.n.) vaccination promotes a Th17 biased immune response. Here, we show that co-administration of a pegylated derivative of a-galactosylceramide (aGCPEG) with an antigen, even in the presence of Th17-polarizing compounds, results in a strong blocking of Th17 differentiation."
"Additional studies demonstrated that this phenomenon is specifically...
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