Vaccines
Research Reports on Vaccines from J.N. Brewoo and Colleagues Provide New Insights
Published in Vaccine Weekly, April 11th, 2012
2012 APR 11 -- Data detailed in "Immunogenicity and efficacy of chimeric dengue vaccine (DENVax) formulations in interferon-deficient AG129 mice" have been presented. "Formulations of chimeric dengue vaccine (DENVax) viruses containing the pre-membrane (prM) and envelope (E) genes of serotypes 1-4 expressed in the context of the attenuated DENV-2 PDK-53 genome were tested for safety, immunogenicity and efficacy in interferon receptor knock-out mice (AG129). Monovalent formulations were safe and elicited robust neutralizing antibody responses to the homologous virus and only limited cross-reactivity to other serotypes," investigators in Madison, Wisconsin report.
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Source: Vaccine Weekly (2012-04-11)
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