Subunit Vaccines

New Subunit Vaccines Study Findings Reported from National Chiao Tung University

Published in Vaccine Weekly, April 18th, 2012

2012 APR 18 -- "Inexpensive liposome-polymer transfection complexes (LPTCs) were developed and used as for DNA or protein delivery. The particle sizes of the LPTCs were in the range of 212.2 to 312.1 nm, and the zetapotential was +38.7 mV," scientists writing in the Journal of Nanomaterials report.

"LPTCs condensed DNA and protected DNA from DNase I digestion and efficiently delivered LPTC/DNA complexes in Balb/3T3 cells. LPTCs also enhanced the cellular uptake of antigen in mouse macrophage cells and stimulated TNF-alpha release in naive mice splenocytes, both indicating the potential of LPTCs as adjuvants for vaccines. In vivo studies were...

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Source: Vaccine Weekly (2012-04-18)

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