Research from M.A. Abdelkrim et al Has Provided New Information about Cardiology

2012 MAY 2 -- Research findings, "Autoantibodies against cardiac ß(1)-adrenoceptor do not affect the low-affinity state ß(1)-adrenoceptor-mediated inotropy in rat cardiomyocytes," are discussed in a new report. "Circulating autoantibodies directed against the 2nd extracellular loop (EL-2) of ß(1)-adrenoceptors (ß(1)-AABs) have been detected in the serum of patients with various cardiovascular pathologies. ß(1)-AABs induce agonistic, positive inotropic effects via ß(1)-adrenoceptors (ß(1)ARs). In the mammalian heart, ß(1)-AR can exist in 2 distinct activated configurations (the so-called high-and low-affinity states)," scientists in...

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