Herpes Simplex Virus
New Herpes Simplex Virus Study Findings Recently Were Published by Researchers at Wayne State University School of Medicine
Published in Vaccine Weekly, May 9th, 2012
2012 MAY 9 -- Research findings, "Synthesis and antiviral activity of 6-deoxycyclopropavir, a new prodrug of cyclopropavir," are discussed in a new report. "Synthesis of 6-deoxycyclopropavir (10), a prodrug of cyclopropavir (1) and its in vitro and in vivo antiviral activity is described. 2-Amino-6-chloropurine methylenecyclopropane 13 was transformed to its 6-iodo derivative 14 which was reduced to prodrug 10. It is converted to cyclopropavir (1) by the action of xanthine oxidase and this reaction can also occur in vivo," scientists in Detroit, Michigan report.
"Compound 10 lacked significant in vitro activity against human cytomegalovirus (HCMV), human...
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Source: Vaccine Weekly (2012-05-09)
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