Waterborne Illness

Assay enables detection of cyanobacterial toxin

Published in Vector and Zoonosis Week, January 13th, 2003

Researchers in Scotland used "a naive (unimmunized) human semisynthetic phage display library ... to isolate recombinant antibody fragments against the cyanobacterial hepatotoxin microcystin-LR."

"Selected antibody scFv genes were cloned into a soluble expression vector and expressed in Escherichia coli for characterization against purified microcystin-LR by competition enzyme-linked immunosorbent assay (ELISA)," wrote J. McElhiney and colleagues.

They said "[t]he most sensitive single-chain antibody (scAb) isolated was capable of detecting microcystin-LR at levels below the World Health Organization limit in drinking water (1 microg/L) and...

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Source: Vector and Zoonosis Week (2003-01-13)

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