Malaria Therapy
Dihydroartemisinin accumulates in cerebrospinal fluid during artesunate treatment
Published in Vector and Zoonosis Week, February 24th, 2003
CSF penetration of "artesunate and DHA was assessed in six adults with cerebral or severe malaria," wrote T. M. E. Davis and colleagues, University of Western Australia.
"Lumbar punctures were performed on admission and during convalescence, at 15 min (patient 1), 30 min (patient 2), 45 min (patient 3), 60 min (patient 4), 90 min (patient 5), and 120 min (patient 6) after intravenous administration of 120 mg of artesunate. No artesunate was detectable in CSF," Davis et al said.
However, "in...
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