Therapy (HCV)

"Cleavage of Viral RNA and Inhibition of Viral Translation by Hepatitis C Virus RNA-Specific Hammerhead Ribozyme in vitro."

Published in Virus Weekly, September 8th, 1997

According to the authors' abstract of an article published in Journal of Hepatology, "Background/Aims: A hammerhead ribozyme has been used as a new way to suppress specific gene expression. We designed hammerhead ribozymes directed against hepatitis C virus RNA, and investigated their cleavage efficiency and inhibitory effect on viral translation in vitro. Methods: Three hammerhead ribozymes bearing different cleavage sites in the core region of hepatitis C virus RNA (genotype 1b) were designed in this study. Ribozymes and the target hepatitis C virus RNA were synthesized by in vitro transcription. The cleavage efficiency was evaluated by the ribozyme cleavage assay. ...

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Source: Virus Weekly (1997-09-08)

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