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"HIV-1 Envelope-Specific CD4+ T Helper Cells from Simian/Human Immunodeficiency Virus-Infected Rhesus Monkeys Recognize Epitopes Restricted by MHC Class II DRB1*0406 and

Published in Virus Weekly, October 20th, 1997

According to the authors' abstract of an article published in Journal of Immunology, "The HIV-1 envelope (Env)-specific Th cell response of rhesus monkeys infected with nonpathogenic chimeric simian/human immunodeficiency viruses (SHIV) was assessed at a molecular level by establishing rgp120-specific CD4+ T-cell lines. Epitopes recognized by these MHC class II-restricted Th cells were identified within the second (C2), third (C3), and fifth (C5) conserved regions of HIV-1 gp120. The epitope located in C2 was found to be restricted by the rhesus monkey (Macaca mulatta) leukocyte Ag Mamu-DRB1*0406, and the Th cell epitope in C5 was found to be restricted by...

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