AIDS Immunology

HIV Progression Slower in Kids Heterozygous for Mutant Gene

Published in Virus Weekly, February 9th, 1998

A gene mutation protects children against HIV disease even better than it protects adults, a French study shows.

The gene encodes the CCR5 receptor, required for infection with the macrophage-tropic (M-tropic) HIV strains responsible for the vast majority of infections. A 32-nucleotide deletion in the CCCR5 gene (CCR5delta32) protects cells against infection with M-tropic HIV strains.

Adults homozygous for CCR5delta32 - that is, those who inherited the mutant gene from both parents - are protected against HIV infection and, when infected, have slower disease progression. Heterozygous adults - who got the gene from only one...

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Source: Virus Weekly (1998-02-09)

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