Published in Virus Weekly, March 30th, 1998
Orthotopic liver transplantation (OLT) is often the only therapeutic option for patients with acute or chronic liver failure caused by viral hepatitis. However, infection of the liver graft by persisting virus is frequent in these patients who receive immunosuppressive medication to prevent graft rejection. Immunosuppressive drugs impair the T-cell response that is necessary to eliminate viral antigens, and corticosteroids can directly stimulate hepatitis B virus (HBV)...
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