Virology (Ebola)

Two Methods of Disease Promotion Identified for Ebola Virus

Published in Virus Weekly, May 18th, 1998

A ground-breaking report from the University of Michigan may explain why the Ebola virus is so virulent.

The report suggests that the transmembrane glycoprotein and a nonstructural smaller glycoprotein promote disease progression using distinct mechanisms. The transmembrane glycoprotein (GP) attaches to endothelial cells, enabling the virus to gain entry, while the non-structural secreted glycoprotein (sGP) binds to neutrophils and inhibits their activation.

"The differential binding of these two gene products from the same viral structural gene generated by RNA editing suggests that they have evolved functionally to differentially affect immunity...

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Source: Virus Weekly (1998-05-18)

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