AIDS Therapies

Amprenavir Useful in Initial and Salvage Treatment

Published in Virus Weekly, August 8th, 2000

The new protease inhibitor (PI) Amprenavir , which recently received marketing approval from the U.S. Food and Drug Administration, can be used in both initial and salvage combination therapies.

"Amprenavir is a potent competitive inhibitor of HIV-1 protease and a relatively weak inhibitor of HIV-2 protease. Inhibition of the HIV-1 protease enzyme results in immature and noninfectious viral particles," said H.B. Fung and colleagues, Bronx Veterans Administration Medical Center, New York ("Amprenavir: A new human immunodeficiency virus type 1 protease inhibitor," Clinical Therapeutics, 2000;22(5):549-572).

According to the researchers,...

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Source: Virus Weekly (2000-08-08)

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