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Opportunistic Infections

Antiretroviral Therapy Reduces Cytomegalovirus in HIV-1 Patients

Published in Virus Weekly, October 17th, 2000

Antiretroviral therapy appears to reduce the number of cytomegalovirus (CMV) infected cells in HIV-1 infected patients.

"Visualization of antigen-specific T cells has become an important tool in studying immune responses," stated V. Grosse and colleagues. "The aim of this study was to analyze CMV-specific CD4+ T cells in healthy and HIV infected individuals."

The researchers examined peripheral blood mononuclear cells (PBMC) for antigen-induced intracellular cytokine responses. They detected significant numbers of CMV-specific CD4+ T cells in most CMV-immunoglobulin G (IgG+) HIV-1 infected individuals, but did not...

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