AIDS Therapies

Iron Chelation May Enhance Treatments

Published in Virus Weekly, March 27th, 2001

by Michael Greer, staff medical writer - Drugs that help remove iron from circulation may be able to improve the effectiveness of existing HIV treatment regimens, virologists in The Netherlands suggest.

"Studies showing that oxidative stress and iron may be important in the activation of HIV-1 have focused attention on the potential therapeutic use of iron chelators," according to B.S. Vanasbeck and colleagues at the University of Utrecht.

Writing in the Journal of Clinical Virology, Vanasbeck et al. described how iron removal can be used to hamstring HIV replication. Reactive oxygen species produced by iron can impair the activity of nuclear...

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Source: Virus Weekly (2001-03-27)

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