Hepatitis C Virus

Overexpression of HCV core protein promotes chronic infection

Published in Virus Weekly, April 29th, 2003

Hepatologists with the University of Dusseldorf have shown that "overexpression of hepatitis C virus core protein inhibits interferon-alpha-induced tyrosine phosphorylation and activation of STAT1 in hepatic cells."

The majority (80%) of patients newly infected with the hepatitis C virus (HCV) will go on to develop chronic infection. This led J.G. Bode and colleagues to hypothesize that "because SOCS molecules have been recognized to be powerful inhibitors of cytokine signaling via the Jak/STAT pathway, virus-induced expression of these molecules should be an efficient instrument to counteract the cellular response toward interferons (IFNs), an essential part of first...

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Source: Virus Weekly (2003-04-29)

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