Ebola Virus

Ebola and lassa viruses target dendritic cells and prevent cytokine release

Published in Virus Weekly, April 29th, 2003

Ebola and lassa viruses target dendritic cells and prevent them from releasing cytokines

According to a study from the United States, "Acute infection of humans with Ebola and Lassa viruses, two principal etiologic agents of hemorrhagic fevers, often results in a paradoxical pattern of immune responses: early infection, characterized by an outpouring of inflammatory mediators such as TNF-alpha, IL-1-beta, and IL-6, vs late stage infections, which are associated with poor immune responses. The mechanisms underlying these diverse outcomes are poorly understood."

"In particular, the role played by cells of the innate immune system, such as dendritic...

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Source: Virus Weekly (2003-04-29)

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