Human Papillomavirus

Antagonists of the E1-E2 protein interaction inhibit HPV DNA replication

Published in Virus Weekly, September 9th, 2003

Small molecule antagonists of the E1-E2 protein interaction inhibited human papillomavirus DNA replication.

"Human papillomavirus (HPV) DNA replication is initiated by recruitment of the E1 helicase by the E2 protein to the viral origin. Screening of our corporate compound collection with an assay measuring the cooperative binding of E1 and E2 to the origin identified a class of small molecule inhibitors of the protein interaction between E1 and E2," researchers in Canada report.

"Isothermal titration calorimetry and changes in protein fluorescence showed that the inhibitors bind to the transactivation domain of E2, the region that interacts with...

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Source: Virus Weekly (2003-09-09)

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