Virus Weekly

Antiretroviral Therapy - Ribinucleotide reductases attenuate efficacy of abacavir

HIV/AIDS Research - Insertion of CD80 (B7.1) and CD86 (B7.2) into HIV-1 affects virus life cycle

Hepatitis C Virus - Chemokines and CCR5 interaction critical in regulating T cell function

Herpesvirus - bis(Thiosemicarbazone) compounds active against wild-type and ACV-resistant HSV

Viral Heart Disease - Viral infection may be responsible for myocarditis

Antiretroviral Drug Resistance - Long-term suppression of HIV RNA with HAART occur despite virus evolution

Antiretroviral Therapy -  Clusiaceae species extracts inhibit HIV-1 reverse transcriptase

Antiretroviral Therapy - Addition of tenofovir decreases AUC for atazanavir in HIV-treated patients

Antiretroviral Therapy - Atazanavir suppresses HIV with extended use and in nelfinavir-switched patients

Antiretroviral Therapy - Microglia-expressed MRPs may restrict permeation of antiretroviral drugs

Antiretroviral Therapy - Mutation D30N not selected by HIV-1 subtype C in nelfinavir resistance

Antiretroviral Therapy - Novel S-DABO derivatives inhibit HIV-1 and HIV-2

Antiretroviral Therapy - Novel fungal polyketide inhibits HIV-1 integrase activity

Antiretroviral Therapy - Novel thia-DCK analogues inhibit HIV replication in vitro

Antiretroviral Therapy - Previous immunosuppression predicts incomplete immune reconstitution after HAART

Antiretroviral Therapy - Sustained HIV virological response better with triple nucleoside therapy

Aplastic Anemia - T-cell repertoire returns to normal in HAA recovery

Avian Influenza - Thailand announces new suspected case of bird flu in humans

Biological Markers - DC-SIGN is a marker for dendritic cells and alternatively activated macrophages

Breast Cancer - Long terminal repeat superantigen might play a role in breast cancer

Cancer Therapy - Biotech company confirms plans to produce Multiferon at Swedish facility

Cardiomyopathy - Dystrophin disruption may contribute to enterovirus-induced myocarditis

Cervical Cancer - Hybrid capture 2 assay and PCR compared as HPV screening tools

Chemokine Receptor - Low pH not required for RANTES or MIP-1beta dissociation from CCR5

Coronavirus - Novel peptides inhibit SARS coronavirus

Coronavirus - SARS-associated coronavirus infection inhibited by immoral immune response

Creutzfeldt-Jakob Disease - In vitro test systems compared

Diagnostics - One-step quantitative RT-PCR assay detects SARS coronavirus

Disease Outbreaks - West Nile, whooping cough cases keep state lab busy

Drug Development - Candidate topical microbicides exhibit several anti-HSV mechanisms

Finance - Global sleep and respiratory company reports financial results

Flavivirus - Live flavivirus vaccines require caution

Foot-and-Mouth Disease Vaccine - Pressure-inactivated foot-and-mouth disease virus is vaccine candidate

Gene Therapy - HSV immortalized T cells are gene therapy model for primary immunodeficiencies

Genomics - Hepatitis B genotype D distinguished from non-D using polymerase chain reaction

HIV Diagnostic - Clinical trial commences for HIV rapid test

HIV/AIDS - Persistent apoptosis in HIV patients associated with poor recovery of CD4 cells

HIV/AIDS Healthcare - Knowledge gap increases HIV contagion fear in nurses in Uganda

HIV/AIDS Prevention - Campaign aimed at reducing HIV infection

HIV/AIDS Prevention - Stigmatization thwarts HIV prevention efforts in Honduras north coast

HIV/AIDS Research - AA substitutions in multidrug-resistant HIV RT leads to drug resensitization

HIV/AIDS Research - HIV fitness loss correlates with poor ability of K65R/L74V RT to use nucleotides

HIV/AIDS Research - New generation of SNV-based vectors may be used to block HIV-1 replication

HIV/AIDS Research - theta-Defensin composed exclusively of D-amino acids active against HIV-1

HIV/AIDS Screening - Use of two HIV antibody screening tests increase false-positive rate

HIV/AIDS Therapy - Immune recovery slows after 3 years HAART and reaches plateau after 4-5 years

HIV/AIDS Transmission - Acceptance of HAART intervention independent of maternal immune status

HIV/AIDS-Associated Lipodystrophy - Rosiglitazone induces gene expression in adipose tissue in HAL patients

HIV/AIDS-Related Disease -  Pneumocystis activates AM NF-KB signaling through mannose receptors

HIV/AIDS-Related Encephalitis - IL-16 expressed in lymphocytes and microglia in HIV-1 encephalitis

HIV/AIDS-Related Lipodystrophy - HIV-related lipodystrophy caused by multiple factors

Hepatitis - New hepatitis B indication filed for PEGASYS filed in U.S., E.U. and Switzerland

Hepatitis A Virus - Health official says no errors made in hepatitis scare

Hepatitis A Virus - Wendy's worker tests positive for hepatitis A in Marion

Hepatitis B Virus - HBV genotypes and precore and core mutants studied in Brazilian patients

Hepatitis C - Hepatitis C virus kinetics and host responses in chimpanzees determined