Virus Weekly

Antiviral Drug Development - Rab9 identified as a novel antiviral drug target

Cytomegalovirus - Human cytomegalovirus-induced host cell enlargement is iron dependent

HIV/AIDS Research - CD4+ cell loss in T-tropic HIV-1 infection is not directly mediated by apoptosis

Kaposi Sarcoma Herpesvirus - KSHV ORF36 protein kinase activates c-Jun N-terminal kinase signaling pathway

Virology - CMV UL76 encodes novel virion-associated protein that inhibits viral replication

AIDS/HIV Diagnosis - OraQuick ADVANCE rapid HIV-1/2 antibody test is sensitive and specific

Addiction Medicine - Injection drug users often develop hepatitis C virus superinfections

Adenovirus - Fiber protein encoded by late region of bovine adenovirus characterized

Agriculture - Researchers uncover how infections combat plant immune responses

Anti-Infective Agents - Sulfamates offer promise as anti-infective/anticancer agents

Antiretroviral Therapy - Antiretroviral CSF penetration improves cognitive disorders in HIV infection

Apoptosis - HTLV-1 Tax oncogene causes tumorigenesis

Bovine Viral Diarrhea - Bovine viral diarrhea virus with deletions protects calves

Business & Finance - Biotechnology company receives $5 million financial commitment

Business Update - Company opens nucleic acid amplification testing laboratory

Business Update - Healthcare marketing company to manage launch of extended-release expectorant

Cancer Research - Pharma company provides Tarvacin IND update

Cancer Research - Study sheds light on how poxviruses can jump from species to species

Cancer Therapy - Patent granted for production and processing of the reovirus

Caprine Arthritis Encephalitis Virus - Caprine arthritis encephalitis virus isolated from sheep during epidemic

Cervical Cancer - Investigational vaccine reduces risk of HPV-related cervical cancer

Chlamydia Pneumoniae Vaccine - DNA vaccine plus booster protects against Chlamydia pneumoniae

Chronic Hepatitis B - Biochemical flares arise in patients with hepatitis B virus mutants

Chronic Hepatitis B - Hepatitis B virus DNA in the liver correlates with extent of liver injury

Chronic Hepatitis C - Viral load and liver enzyme levels fluctuate in hepatitis C-infected patients

Dengue Vaccine - Dengue infection enhanced by sera from dengue-vaccinated children

Diagnostics - A new assay improves the timeliness and sensitivity of hepatitis C detection

Diagnostics - Archival cytologic samples suitable for PCR testing

Diagnostics - Core antigen assay can't confirm active hepatitis C virus infection

Diagnostics - Diagnostic kit maker receives approval to export Vscan test kits from China

Diagnostics - Diagnostics company donates rapid HIV tests in China

Drug Development - Light-directed gene delivery shows promise for therapeutic use

Epidemiology - Human disease outbreaks are bioindicators of ecologic well-being

Epstein-Barr Virus - Rheumatoid factors induce signaling from B cells and lead to EBV activation

Flu Vaccine - Arkansas flu shots almost gone

Flu Vaccine - Hawaii to hold flu shot clinics for chronically ill

Flu Vaccine - Minnesota nursing homes report they have enough flu vaccine

Genital Herpes - Viral shedding explored as a surrogate marker for genital herpes transmission

HIV/AIDS Epidemiology - Doctors Without Borders says children with HIV/AIDS dying needlessly

HIV/AIDS Drug Resistance - Incomplete HIV suppression may account for resistant mutations in brain

HIV/AIDS Epidemiology - Use of blood donor data for HIV surveillance does not reflect normal population

HIV/AIDS Genetics - HIV-1 recombination is a major evolutionary force affecting genetic variation

HIV/AIDS Pathogenesis - Non-syncytia-inducing HIV inhibits replication of syncytia-inducing strains

HIV/AIDS Perinatal Transmission - Nevirapine does not prevent perinatal HIV-1 transmission in the field

HIV/AIDS Prevention - Global communication effectively transfers HIV prevention strategies

HIV/AIDS Research - 2-Aminopurine fluorescence binding assay quantitates HIV-1 TAR interactions

HIV/AIDS Research - CD4 infection with infectious HIV-1 leads to IL-2 promoter hyper-responsiveness

HIV/AIDS Research - Conserved carboxy terminus of HIV-1 Gag important for virion assembly/release

HIV/AIDS Research - Cyoplasmic p53 may enhance the accuracy of HIV-1 RT DNA synthesis

HIV/AIDS Research - Determinants within gp120 and gp41 contribute to CD4 independence of SIV Env

HIV/AIDS Research - HIV-1 integration sites flanked by potential MARs can act as promoters

HIV/AIDS Research - HIV-infected CD8 lymphocytes generated through infection of activated CD8 cells

HIV/AIDS Research - Hsp70 protects cells from cell cycle arrest and apoptosis induced by HIV-1 Vpr

HIV/AIDS Research - IgMs selectively cleave HIV gp120 by a nucleophilic mechanism

HIV/AIDS Risk - Adolescent woman may be more susceptible to HIV infection than men in Cameroon

HIV/AIDS Screening - HIV screening inadequate in North Carolina jails

HIV/AIDS Therapy - Antiretroviral treatment decisions based on toxicity/resistance/convenience

HIV/AIDS Therapy - Each nucleoside/nucleotide backbone of HIV therapy has its advantages

HIV/AIDS Therapy - HIV viral load after 4 weeks of HAART predicts virologic outcome at 24 weeks

HIV/AIDS Therapy - Improved activity of abacavir prodrug due to increased CBV-TP metabolites

HIV/AIDS Therapy - Marketing authorization application submitted for Tipranavir

HIV/AIDS Therapy - Mechanism elucidated for bleomycin inhibition of HIV-1

HIV/AIDS Therapy - NRTIs decrease mitrochondrial DNA synthesis and oxidative enzyme content