HIV/AIDS Research

CD4+ cell loss in T-tropic HIV-1 infection is not directly mediated by apoptosis

Published in Virus Weekly, November 23rd, 2004

CD4+ T-lymphoctye loss in T-tropic HIV-1 infection is not directly mediated by apoptosis.

According to recent research published in the journal Virology, "Disease progression in human immunodeficiency virus type-1 (HIV-1)-infected individuals is frequently accompanied by declining CD4 cell numbers and the acquisition of a T-tropic (X4) or dual tropic (R5X4) phenotype.

"Understanding the mechanism of CD4 cell loss in HIV-1 infection is essential for the development of effective therapeutic strategies. In this study, donor populations of peripheral blood mononuclear cells (PBMCs) were selected for their ability to support an equivalent acute...

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Source: Virus Weekly (2004-11-23)

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