Virology

CMV UL76 encodes novel virion-associated protein that inhibits viral replication

Published in Virus Weekly, November 23rd, 2004

The human cytomegalovirus UL76 gene encodes a novel virion-associated protein that inhibits viral replication.

According to a study from Taiwan, "The human cytomegalovirus (HCMV) UL76 gene encodes a highly conserved herpesvirus protein, pUL76, which is able to modulate gene expression in either activation or repression.

"In this study, two specific transcripts were found to contain the reading frame of UL76, one a 4.5-kb and the other a 5.5-kb tricistronic mRNA encoding the UL76, UL77, and UL78 open reading frames. Both transcripts were expressed with true late kinetics, as revealed by data showing inhibition of production in the presence of...

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Source: Virus Weekly (2004-11-23)

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