Virus Weekly

Drug Development - Thymalfasin may treat patients with chronic hepatitis B

HIV/AIDS Pathogenesis - HIV-1 can dysregulate CD4+ T cells that express CXCR4

HIV/AIDS Research - Cellular adhesion to VCAM-1 mediated by VLA-4 is suppressed after treatment

HIV/AIDS Research - HIV LTR-dependent Bax expression selectively induces apoptosis in Tat+ cells

HIV/AIDS Therapy - Drugs to inhibit drug-resistant HIV reverse transcriptases developed

Adenoviral Vectors - Adenoviral vectors used, CFTR expression and properties clarified

Allergy and Immunology - Anhydrase II antibody is not a prognostic marker of autoimmune pancreatitis

Allergy and Immunology - Circulating dendritic cells fall short in hepatitis B virus-infected humans

Biomedical Engineering - Nanobiohybrids implement fluorescent protein transfection

Blood Donation - Rights of blood recipients should supersede any asserted rights of blood donors

Business Update - Cobra extends its agreement to provide long-term manufacture of REOLYSIN

Business Update - Infection prevention company's decontamination technology included in report

Cancer Therapy - Common virus becomes a new target for cancer treatment

Canine Distemper Virus - Hemagglutinin gene of canine distemper viruses analyzed

Cervical Cancer - Researchers' findings advance cervical cancer research

Chronic Hepatitis C - Triple combination therapy benefits previous hepatitis C non-responders

Chronic Liver Disease - Metallothionein gene therapy reverses liver fibrosis in mice

Chronic Liver Disease - Nonalcoholic fatty liver disease affects patients with hepatitis C adversely

Colon Cancer - Ritonavir may curb colon carcinogenesis via apoptosis/inflammatory modulation

Cytomegalovirus Vaccines - Findings describe new data in cytomegalovirus vaccines research

Dendritic - DC-SIGN tetramers essential for high affinity interactions with HIV

Dengue Fever - New findings in dengue fever described

Dengue Outbreak - Integrated therapeutic/public health response controls dengue outbreak

Diabetes Risk Factors - Hepatitis C virus infection triggers diabetes in liver graft recipients

Diagnostics - Qualitative multiplex RT-PCR offers simultaneous detection of HIV and HCV

Diagnostics - Researchers' data advance diagnostics research

Disease Associations - Influenza A virus PB1-F2 protein studied, mitochondrial function revealed

Disease Transmission - In Uganda, poverty is affecting AZT use among mothers

Drug Development - Intrapleural gene therapy may cure human alpha1-antitrypsin deficiency

Emerging Viral Infections - Emergent viral infections often due to crossing species barrier

Encephalitis - Gene dysregulation found in cortex of HIV encephalitis patients

Enzymology - Recent findings illuminate research in enzymology

Finance - Pharmaceutical company announces 2004 financial results

HIV/AIDS Clinical Studies - Device maker to initiate HIV trials in India

HIV/AIDS Diagnostics - Diagnosis not always self-evident in early stage of HIV-associated wasting

HIV/AIDS Diagnostics - HIV antibody/antigen assays perform better than antibody-only assays

HIV/AIDS Diagnostics - Research shows HIV screening is cost effective

HIV/AIDS Drug Development - Active site conformation used for HIV-1 integrase inhibitor design

HIV/AIDS Drug Development - Hops Humulus lupulus extract inhibits HIV replication

HIV/AIDS Drug Development - Thia-DCK analogs inhibit HIV-1

HIV/AIDS Drug Monitoring - Intracellular pharmacology of protease inhibitors improves therapeutic efficacy

HIV/AIDS Lipodystrophy - IGFBP-3 protease significant regulator of bioactive IGF-I in HIV-lipodystrophy

HIV/AIDS Opportunistic Infection - C-18 mutations critical for CCR5-binding/HIV-1 fusion inhibition

HIV/AIDS Pathogeneis - HIV-1 envelope facilitates contagious apoptosis

HIV/AIDS Pathogenesis - Plasma IL-18 associated with viral load/disease progression in HIV-1-infection

HIV/AIDS Pathogenesis - SOCS box in HIV-1 Vif that mediates its interaction with ElonginC characterized

HIV/AIDS Pathogenesis - T-cell activation leads to poor activation of HIV-1 clade E LTR

HIV/AIDS Pathogenesis - Thioester stability does not correlate significantly with anti-HIV-1 activity

HIV/AIDS Prevention - Chinese rural-to-urban migrants participate in AIDS prevention programs

HIV/AIDS Prevention - New AIDS organization aimed at black college students

HIV/AIDS Research - APOBEC3B and APOBEC3C are potent inhibitors of SIV replication

HIV/AIDS Research - Evans Blue inhibits NF-kappaB-DNA binding

HIV/AIDS Research - SOCS-box phosphorylation regulates assembly of HIV-1 Vif-Cul5 complex

HIV/AIDS Therapy - Difference in median CD4 increase in HIV subtype B vs. non-B after PI therapy

HIV/AIDS Therapy - Entry inhibitor BMS-378806 may have reduced efficacy against non-B HIV-1

HIV/AIDS Therapy - New research in the area of HIV/AIDS therapy detailed

HIV/AIDS Therapy - Studies describe new findings in HIV/AIDS therapy research

HIV/AIDS Treatment - Time delay model shows possible effects of HAART on HIV dynamics

HIV/AIDS Vaccine - Advances in diagnosis and treatment of acute HIV-1 infection reviewed

HIV/AIDS Vaccine - Collaborators expand phase 1 clinical trial of HIV/AIDS vaccine program to India

HIV/AIDS Vaccine - Conformational changes during T cell receptor engagement reported

HIV/AIDS Vaccine - HIV induces and maintains suppression of thymocyte proliferation