HIV/AIDS Pathogenesis
Separate HIV Nef domains are required to affect MHC-1 and CD4 cells
Published in Virus Weekly, April 5th, 2005
"Human immunodeficiency virus type 1 (HIV-1) Nef is a critical protein that is necessary for HIV pathogenesis. Its roles include the disruption of major histocompatibility complex class I (MHC-I) and CD4 trafficking to promote immune evasion and viral spread.
"Mutational analyses have revealed that separate domains of Nef are required to affect these two molecules," investigators in the United States report.
"To further elucidate how Nef disrupts MHC-I trafficking in T cells," wrote M. Williams and colleagues at the University of Michigan, "we examined the role...
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Source: Virus Weekly (2005-04-05)
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