HIV/AIDS Research
Tat methylation by PRMT6 regulates HIV-1 gene expression
Published in Virus Weekly, April 5th, 2005
According to recent research from Canada, "The human immunodeficiency virus (HIV) transactivator protein, Tat, stimulates transcription from the viral long terminal repeats via an arginine-rich transactivating domain.
"Since arginines are often known to be methylated, we investigated whether HIV type 1 (HIV-1) Tat was a substrate for known protein arginine methyltransferases (PRMTs). Here we identify Tat as a substrate for the arginine methyltransferase, PRMT6."
"Tat is specifically associated with and methylated by PRMT6 within cells. Overexpression of wild-type PRMT6, but...
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Source: Virus Weekly (2005-04-05)
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