Influenza Vaccine
Acidic polymerase epitope of influenza elicits potent antiviral response
Published in Virus Weekly, April 5th, 2005
"The mechanisms underlying epitope selection and the potential impact of inummodominance hierarchies on peptide-based vaccines are not well understood. Recently, we have shown that two immumodominant MHC class I-restricted epitopes, NP366-374 /Db (nucleoprotein, NP) and PA224-233 /Db (acidic polymerase, PA), which drive the CD8+ T cell response to influenza virus infection in C57BL/6 mice, are differentially expressed on infected cells. Whereas NP appears to be...
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Source: Virus Weekly (2005-04-05)
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