Published in Virus Weekly, April 5th, 2005
"The mechanisms underlying epitope selection and the potential impact of inummodominance hierarchies on peptide-based vaccines are not well understood. Recently, we have shown that two immumodominant MHC class I-restricted epitopes, NP366-374 /Db (nucleoprotein, NP) and PA224-233 /Db (acidic polymerase, PA), which drive the CD8+ T cell response to influenza virus infection in C57BL/6 mice, are differentially expressed on infected cells. Whereas NP appears to be...
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