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Oncology

Oncolytic virus and radiotherapy join to treat squamous cell carcinoma

According to recent research published in the European Journal of Cancer, "G207 is an oncolytic herpes simplex virus (HSV) with deletions at both gamma₁ 34.5 loci and a LacZ gene insertion inactivating the HSV ribonucleotide reductase gene. Ionizing radiation induces the growth arrest-inducible gene, GADD34, and ribonucleotide reductase. GADD34 is a protein that correlates with apoptosis following radiation and has homology with the G207 gamma₁ 34.5 gene."

"We hypothesized that the combination of radiotherapy with G207 may have a potentiating effect...

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