Virus Weekly

Disease Associations - Cytomegalovirus retinitis analyzed, infection of retinal neurons revealed

Influenza - Alphavirus fusion proteins studied, membrane fusion pathways clarified

Vaccine Adjuvant - Pseudorabies virus harboring IgG Fc domain protects mice from challenge

Vaccinia Virus - SUMO-1 modification of vaccinia virus protein prevents its self-association

West Nile Virus Vaccine - Vaccine protects dogs and cats against a mosquito West Nile virus challenge

Adenovirus - Coxsackievirus and adenovirus receptor studied, extracellular domain defined

Animal Studies - Single-cycle SIV immunization reduces viral loads after SIV_mac 239 challenge

Atherosclerosis - Infectious burden is not associated with inflammation in dialysis patients

Bovine Herpesvirus - CD11b+ PBLs main target cell populations in blood for bovine herpesvirus 4

Business Update - U.K. investment firm reiterates buy recommendation on pharmaceuticals company

Diagnostics - Researchers publish new studies and findings in the area of diagnostics

Cancer Detection - The ANN/TM-GTP index accurately predicts recurrent liver cancer

Cancer Risk Factors - Sustained attenuation of hepatitis B DNA abates liver cancer risk

Cancer Treatments - Model of deoxycytidine kinase specific for purine nucleosides developed

Cervical Cancer Vaccine - Immune responses induced by HPV type 16 virus-like particle vaccine

Chagas Disease - Researchers identify protein machinery of Chagas disease parasite

Chickenpox Epidemiology - Reliability of varicella history in children and adolescents examined

HIV/AIDS Pathogenesis - Reports describe recent advances in HIV/AIDS pathogenesis research

Chronic Hepatitis B - Female gender and low platelet counts favor hepatitis B response to lamivudine

Chronic Liver Disease - Ethnic differences govern survival after intrahepatic shunt placement

Chronic Liver Disease - The hepatic sympathetic nerve protects against Fas-induced liver injury

Cirrhosis - Hemochromatosis gene mutations worsen liver disease in viral hepatitis patients

Collaborations - Waiting period expires for exclusive collaboration with Novartis

Complementary and Alternative Medicine -  Polygonum cuspidatum limits hepatitis B virus production

HIV/AIDS Vaccines - Recent findings in HIV/AIDS vaccines described

Congenital Heart Disease - Study determined factors associated with RSV infection risk in preterm infants

Cytomegalovirus - New findings in cytomegalovirus described

Diabetes Risk Factors - Diabetes cases rise in areas where hepatitis C virus is endemic

Diagnositcs - Diagnostic test kits receive approval in additional countries

Diagnostics - CE Mark certification granted for HIV-1 real-time PCR viral load test

Diagnostics - Cd4+ lymphocytopenia, juvenile laryngeal papillomatosis are associated

HIV/AIDS Vaccines - Recent findings in HIV/AIDS vaccines provide new insights

Diagnostics - Gp210-c terminal peptide antibody titers monitor primary billiary cirrhosis

Diagnostics - Recent findings in diagnostics provide new insights

Drug Development - Pharma company provides development pipeline update

Drug Development - Researchers investigate reovirus-based therapy in battle against cancer

Drug Development - U.S. FDA issues approval for Aurobindo for AIDS

HIV/AIDS Vaccines - Research in HIV/AIDS vaccines provides new insights

Drug Development - U.S. FDA issues final approval for Stavudine for AIDS

Drug Development - U.S. IND submitted for Neugene antisense drug targeting hepatitis C virus

Drug Safety - U.S. FDA-approved labeling for immune system drug includes assurance of purity

Ebola Hemorrhagic Fever - Ebola virus and virus-like particle release analyzed

Emerging Pathogen - Primate T-lymphotropic viruses reported in African bushmeat hunters

End Stage Kidney Disease - Hepatitis B vaccine raises antibody in HIV-infected hemodialysis patients

Influenza Vaccines - Researchers' findings advance influenza vaccines research

Enzymology - DNAzymes control Epstein-Barr virus-related oncogenesis

Epstein-Barr Virus - Findings in epstein-barr virus provide new insights

Feline Leukemia Virus Vaccine - Vector developed as adjuvant for DNA vaccine against feline leukemia virus

Gene Therapy - Adenoviral vector corrects medium-chain acyl CoA dehydrogenase deficiency

HIV/AIDS & Tuberculosis Coinfection - HIV infection may not be associated with drug resistant tuberculosis

HIV/AIDS Coinfection - Asymptomatic syphilis detected more frequently in HIV patients

Virology - Research add new data to virology body of knowledge

HIV/AIDS Diagnostics - MRSI used to assess neuronal function in HIV-1-associated dementia

HIV/AIDS Drug Adherence - Stavudine adherence improves with switch to once-daily dosing

HIV/AIDS Drug Development - Directed evolution creates new PDZ domains for HIV protease activity detection

HIV/AIDS Drug Development - Human cell factor(s) inhibit HIV reverse transcriptase

HIV/AIDS Drug Development - Oximinoarylsulfonamides inhibit HIV protease

HIV/AIDS Drug Development - South African medicinal plant extracts inhibit HIV-1 RT/integrase

Virology - Studies add new findings to virology body of knowledge

HIV/AIDS Drug Resistance - FHIV-1 L89M mutation is high genetic barrier to accumulation of L90M mutations

HIV/AIDS Drug Side Effect - HIV medications impact speech and hearing

HIV/AIDS Drug Side Effect - High OPG levels may protect against bone resorption in HIV patients on HAART

HIV/AIDS Economics - Economic implications of AIDS may be serious for India in the future

HIV/AIDS Epidemiology - High HIV transmission rates in Africa due to high rates of other untreated STIs

HIV/AIDS HAART - Abacavir + efavirenz effective PI alternative in heavily pretreated HIV patients

HIV/AIDS HAART - HAART initiation will alter the biology and evolution of HIV/AIDS in India

HIV/AIDS HAART - Improved response to HAART may also be attributable to adherence/tolerability

HIV/AIDS HAART - Low-cost assays can monitor HAART patients in developing countries

HIV/AIDS Heart Disease - Ritonavir impairs vasomotor function/reduces coronary artery eNOS expression

HIV/AIDS Pathogenesis - APOBEC3G ubiquitination by HIV-1 Vif-BC-Cul5 is essential for Vif function

HIV/AIDS Pathogenesis - Data advance knowledge in HIV/AIDS pathogenesis research

HIV/AIDS Pathogenesis - Fitness differences of 2 HIV-1 isolates related to cell binding/entry efficacy

HIV/AIDS Pathogenesis - HIV Nef establishes superinfection immunity by downregulating CCR5 and CD4

HIV/AIDS Pathogenesis - HIV Nef protein promotes survival of infected cells

HIV/AIDS Pathogenesis - HIV without polypurine tract mutations can replicate at low level

HIV/AIDS Pathogenesis - HIV-1 Tat concomitantly downregulates caspase-10/upregulates c-FLIP in T cells

HIV/AIDS Pathogenesis - Mutant Vif proteins incapable of modulating viral infectivity

HIV/AIDS Postexposure Prophylaxis - TDF-3TC-d4T most tolerated regimen for nonoccupational postexposure prophylaxis

HIV/AIDS Prevention - New findings in HIV/AIDS prevention described